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Cuyahoga Valley Terminal - Models a fictional railroad that covers from Cleveland to Mineral City, Ohio during the 1950s
Keystone Model Railroad Historical Society - HO scale modular club in Mechanicsburg, Pennsylvania
Metrowest Model Railroading Society - O scale club in the Greater Boston, Massachusetts area
Muskoka Model Railway Club - HO and N scale club in Bracebridge, Ontario, Canada
Rose-Hulman Model Railroad Club - Model train club at Rose-Hulman Institute of Technology; Terre Haute, Indiana
Toy Train Operating Society: Buckeye Division - Operates model trains at monthly meetings in central Ohio
Toy Train Operating Society: Empire & Eastern Division - Toy train operators and collectors in eastern New York State
Youngstown Model Railroad Club - HO and O scale club in Youngstown, Ohio
- Aberfoyle Junction - 1500 square foot O gauge model railway depicting Southern Ontario in the late 1950s; Aberfoyle, Ontario, Canada
- Abington Lines Model Railroad Club - HO scale club in Richboro, Pennsylvania
- Altoona Association of Model Railroaders - HO and O scale model railroad layout in Altoona, Pennsylvania
- Amherst Railway Society - 500 members who share some aspect of railroading as a common interest; Amherst, Massachusetts
- Ammonoosuc Valley Railway Association - Model railroad and railroad enthusiasts in New Hampshire
- Ann Arbor Model Railroad Club - HO scale club located at the historic Michigan Central Depot in Dexter, Michigan
- Anthracite Model Railroad Club - HO model railroad club in Hazleton, Pennsylvania
- Atlantic Coast S Gaugers - Promoting S gauge model railroading along the East Coast
- Baltimore Area N-track - N scale club in Baltimore, Maryland
- Baltimore Society of Model Engineers - HO and O scale layouts, plus railroad history displays; Baltimore, Maryland
- Bay State Model Railroad Museum - HO, HOn3, O, and N gauge layouts in Roslindale, Massachusetts
- Beaver County Model Railroad and Historical Society - Home of the Union Atlantic Railroad HO scale model railroad display; Monaca, Pennsylvania
- Bedford Boomers - Model railroad club with an annual convention in Bedford, New Hampshire
- Blissfield Model Railroad Club - Operates a two-level HO scale layout with a focus on the Chesapeake & Ohio and Clinchfield railroads in northeastern Kentucky and western West Virginia; Blissfield, Michigan
- Boothe Memorial Railway Society - Operates O, HO, N, and G scale layouts in Stratford, Connecticut
- Breton Model Railway Club - HO and G scale club in Sydney, Nova Scotia, Canada
- Bristol S Gauge Railroaders - S scale, narrow gauge (Sn3 and Sn2), Hi-Rail, and American Flyer operating and collecting in eastern Massachusetts
- Buckeye Division 6, NMRA - Ohio division of the NMRA's Mid–Central Region
- Bullthistle Model Railroad Society - Operates O, O27, and N scale layouts; Norwich, New York
- Bunker Hill Train Club - Model railroad club in Bunker Hill, West Virginia
- Burlington County Model Railroad Club - Operates the HO scale Rancocas Valley Lines in Cinnaminson, New Jersey
- Campbellton Model Railroad and Heritage Railroad Museum - Historical artifacts and model railroad depicting the transition era of steam to diesel; Campbellton, New Brunswick, Canada
- Cape Cod Model Railroad Club - Located in a baggage car and caboose in West Barnstable, Massachusetts
- Capital Area Railway Society - HO modular model railroad club based in Lansing, Michigan
- Capital PenNScalers NTrak - N scale club in the greater Harrisburg, Pennsylvania area
- Carbon Model Railroad Society - Carbon County, Pennsylvania
- Catskill, Adirondack & Berkshire Railroad, The - HO scale modular club in upstate New York
- Central Connecticut G Gaugers - Operates a 50' x 14' layout with mostly 1:22.5 and 1:29 scales
- Central Indiana Division, NMRA - Division of the Midwest Region, serving the Indianapolis, Indiana area
- Central Indiana Railroad Operators (CIRROPS) - Model railroaders interested in promoting and participating in prototypical operations
- Central New York Division, NMRA - Division of NMRA's Northeastern Region
- Central New York Large-Scale Railway Society - G scale garden railroad and indoor train layout in Cicero, New York
- Central New York Model Railroad Club & Historical Society - HO scale modelers of the Delaware & Ontario Railroad in Hartlot, New York
- Central New York Modelers (CNYMOD) - HO scale model railroad club in Syracuse, New York
- Central Ohio Model Railroad Club - Operates HO, O, and G scale layouts in Columbus, Ohio
- Central Ohio S Gaugers - Members operate Hi-Rail, American Flyer, scale, and narrow gauge S model trains
- Central Ontario Garden Railway Association - Garden railroad club in Georgetown, Ontario, Canada
- Central Operating Lines Model Railroad Club - O gauge train collectors, operators, and modelers in Ronkonkoma, Long Island, New York
- Chatham Model Railroad Club - HO modular layout transported to many events within Ontario; Chatham, Ontario, Canada
- Chatham, Wallaceburg & Lake Erie Model Railroad Group - Club in Wallaceburg, Ontario, Canada
- Chelten Hills Model Railroad Club - HO scale layout with over 1750 feet of double track in Elkins Park, Pennsylvania
- Chesapeake, Allegheny & Blue Ridge Large Scale Railway Society - Large scale 1 gauge and G gauge model train enthusiasts within an 80 mile radius of Washington, DC
- Choo Choo Barn - 1700 square foot model train display with O, HO, and N scales in Strasburg, Pennsylvania
- Cincinnati Division, NMRA - Cincinnati, Ohio division of the Mid-Central Region
- Coal Division 9, Mid Central Region, NMRA - Serves West Virginia, southeastern Ohio, and northeastern Kentucky
- Columbus Garden Railway Society - Garden railroaders in Worthington, Ohio
- Concord Model Railroad Club - HO layout depicting the Boston & Maine trackage north of Concord; Concord, New Hampshire
- Connecticut G-Scalers - Informal garden railroad club in Connecticut
- Connecticut S Gaugers - Informal group of individuals from Connecticut and neighboring states who operate S gauge trains
- Connecticut Valley Model Railroad Club - HO and N scale modular layouts, railroad preservation, railfanning, and rail history; Lebanon, New Hampshire
- Cooke Road Train Crew - Informal club in Columbus, Ohio for railfanning and model railroading
- Coopersburg Area Society of Model Engineers - Building an HO scale layout in Coopersburg, Pennsylvania
- Crescent Central Station - Home of the Crescent Model Railroaders, an O-gauge hi-rail modular club located in the Washington, DC area
- Crossroads Railroad Club - Railroad club with HO and N scale layouts in Vandalia, Ohio
- Cuyahoga Valley S Gauge Association - Informal group of S gauge model railroaders in Ohio
- DARN N-Trak - N-Trak modular club in Delaware County, Pennsylvania
- Delaware Seaside Railroad Club, Inc. - All gauge railroad club based in the Georgetown Historical Railroad Station in Georgetown, Delaware
- Delaware Valley Hi-Railers - Modular O gauge club in southeastern Pennsylvania
- Delmarva Model Railroad Club - Operates HO, O, and N scale layouts in Delmar, Delaware
- Detroit Model Railroad Club - O scale club in Holly, Michigan
- Division 5, North Central Region, NMRA - Lansing, Michigan
- Division 8, Mid-Central Region - Local chapter of the NMRA for Central Kentucky and Southern Indiana
- Division 8, North Central Region, NMRA - Connecting model railroaders in Macomb, Oakland, and St. Clair counties of Michigan
- Division One, North Central Region, NMRA - Toledo, Ohio
- East Penn Traction Club - Trolley modeling group in Philadelphia, Pennsylvania
- Eastern Loggers Model Railroad Club - Operates a layout based on the logging railroad era in Pennsylvania
- Eastern Maine Model Railroad Club - HO scale layout and reference library in East Orland, Maine
- Eastern O Scalers - O scale club sponsors train shows in Wind Gap and Denver, Pennsylvania
- Eastern States Limited Editions Society - Offers members limited edition O scale freight cars of eastern US railroads
- Elkhart Model Railroad Club - Operates HO and N layouts in Elkhart, Indiana
- Ellicott City Station - Oldest railroad station in America, built in 1831 on the B&O Railroad, houses an HO gauge model railroad; Ellicott City, Maryland
- Erin Mills Model Railroad Association - HO and N scale portable modular layouts; Mississauga, Ontario, Canada
- European Train Enthusiasts Central New York Chapter - Serves fans of European prototype and model trains in Central New York
- European Train Enthusiasts Eastern New England Chapter - Individuals with a wide diversity of sub-interests within the hobby of European railroading
- Flower City Tinplate Trackers - 3 rail O gauge modular hi-rail club in Rochester, New York
- Four County Society of Model Engineers - HO scale modular railroad club with a large portable railroad in central Maryland
- Free-Modu-Rail de la Capitale - HO modular club in Québec City, Canada
- Garden State Central Model Railroad Club - HO scale club in Asbury Park, New Jersey
- Garden State Division, NMRA - New Jersey division of the NMRA's Northeastern Region
- Garden State Model Railway Club, Inc. - HO club in North Haledon, New Jersey
- GATSME Lines Model RR Club - Operates an HO scale DCC layout set in 1954; Fort Washington, Pennsylvania
- Genesee G Gauge Railway Society - Large scale model railroad club based in Rochester, New York
- Genesee Society of Model Engineers - Operates HO and O scale layouts in Oakfield and sponsors a train show in Batavia, New York
- Grand Rapids Model Railroad Historical Society - HO scale model railroad club in the Grand Rapids area sponsors an annual train show in Holland, Michigan
- Gratiot Valley Railroad Club - HO scale model railroad club sponsors two annual train shows in Warren, Michigan
- Greater Cincinnati Chapter of the Garden Railway Society - Provides a means for members to exchange ideas, learn, and enjoy the hobby of large scale indoor/outdoor model railroading; Cincinnati, Ohio
- Greater Cincinnati Modular Railroad Association - HO scale modular railroad club with a large portable layout for shows in the Cincinnati, Ohio area
- Green Mountain Division, NMRA - Model railroad club in Vermont
- Hagerstown Model Railroad Museum - Model railroad club at the Norfolk & Western Antietam station in Sharpsburg, Maryland
- Half Nuts Model Railroaders - Informal group of railroad modelers in Summerside, Prince Edward Island, Canada
- Halifax Model Railway Club - O, OO, HO, N, and 009 gauge club in Halifax, Nova Scotia, Canada
- Harford Association of Railroad Modelers - Operates member layouts which range in scale from N to G; Haford County, Maryland
- Hartmann Model Railroad - Museum features many operating layouts from Z to G scale in Intervale, New Hampshire
- HO Model Engineers Society (HOMES) - HO scale club in Hamilton, Ontario, Canada
- Hopewell Junction Model Railroad Club - HO scale modular layout depicts Hopewell Junction NY in the 1920s; Hopewell, New York
- HOTrack of the Sunrise Trail - HO modular club in Long Island, New York
- Housatonic Model Railway Club - Operates an HO scale layout in Fairfield, Connecticut
- HUB Division, NMRA - Serves eastern Massachusetts and Cape Cod
- Hudson Valley Märklin Club - Marklin fans in the Hudson Valley, New York area
- I 80 Group - Division 11 of the NMRA's Mid-Central Region, serving western Pennsylvania
- Independent Hi-Railers Eastern Division - Modular train club operates O gauge trains from all eras in New Jersey and eastern Pennsylvania
- International Division, NMRA - Division of the NMRA for Niagara (Canada) and northwestern New York
- Japan Rail Modelers (JRM) of Washington DC - Japanese N scale modelers in the Washington DC area with a layout displayed at shows
- Jersey Central N-TRAK - Modular N scale club in Tinton Falls, Monmouth County, New Jersey
- Jersey Valley Model Railroad Club - HO scale layout in Hamilton, New Jersey
- John Mc Fadden Model Railroad Museum - Operating layouts and public display of O and O-27 model trains from AMT, American Flyer, Atlas, K-Line, KMT, Lionel, Marx, Plasticville, and others spanning the 1920s to present; Mercersburg, Pennsylvania
- Kalamazoo Model Railroad Historical Society - HO scale club in Kalamazoo, Michigan
- Keystone Division, NMRA - Division of the Mid-Central Region, serving Western Pennsylvania, West Virginia, and surrounding areas
- Keystone N-Trak - N scale club in Lansdale, Pennsylvania
- Kruger Street Toy & Train Museum - O and HO gauge train layouts; Wheeling, West Virginia
- Lake Erie N Scale Society - Ntrak modular club in northeast Ohio
- Lake of the Woods Model Railroaders - HO club working to re-assemble a large layout which was donated to the Lake of the Woods CPR museum; Kenora, Ontario, Canada
- Lansing Area N-Trak (LaNTrak) - N scale club in the Lansing, Michigan area
- Lansing Model Railroad Club - HO scale layout in the former Grand Trunk Millett Depot in Millet, Michigan
- Laurel Highlands Model Railroad Club - Somerset, Pennsylvania
- Lehigh Valley Large Scalers - Large scale train enthusiasts in the Lehigh Valley of Pennsylvania
- Lehigh Valley S Gaugers - Enthusiasts in S scale, hi-rail, American Flyer, and narrow gauge in Allentown, Pennsylvania
- Liberty Hi-Railers - 3-rail O gauge modular Hi-Rail club in Pennsylvania
- Little Rhody Division, NMRA - Serves Rhode Island and southeastern Massachusetts
- Logan Model Engineers - Operates an HO scale railroad in Souderton, Pennsylvania
- London Model Railroad Group - Operates an O scale layout representing a fictitious railroad in Canada along the northern shore of Lake Erie; London, Ontario, Canada
- Long Island Garden Railway Society - Garden railroading club in Long Island, New York
- Long Island Model Railroad Engineers - HO and N scale layouts in Suffolk County, New York
- Loose Ties Model Railroad Club - Modular model train club in Lewisburg, Pennsylvania
- Lorain County Model Railroad Association - Model railroad club in Lorain County in northern Ohio
- Lower Anthracite Model Railroad Club - 3500 sq ft HO scale Shamokin Valley Lines; Shamokin, Pennsylvania
- Maine S Gaugers - Informal group of 1/64 model railroading enthusiasts in Maine
- MaiNe Track - N scale modular club in southern Maine
- Marion Model Railroad Club - HO scale club housed in a historic train station in North Central Ohio, with a layout representing the Ohio diesel era along with traction and narrow gauge branchlines; Marion, Ohio
- Maritime Federation of Model Railroaders - Association of model railroaders in Canada's Maritime Provinces of New Brunswick, Nova Scotia, and Prince Edward Island
- Mason Dixon Large Scale Railroad Society - G scale model railroaders in and around Harford County, Maryland
- McKeesport Model Railroad Club - 40x80' HO scale layout depicting a coal and steel-hauling line from Baltimore to Chicago, loosely along the path of the Baltimore & Ohio Railroad; McKeesport, Pennsylvania
- Metro North Division, NMRA - Serving model railroaders in Westchester County, New York and Fairfield County, Connecticut
- Miami Valley Division, NMRA - Division 3 of the Mid Central Region, serving rail modelers and railfans in the Miami Valley and Dayton area of southwestern Ohio
- Miami Valley Garden Railway Society - Garden railway club in Beavercreek, Ohio
- Miami Valley S Gaugers (MVSG) - S gauge modular club serving the southwest Ohio area
- Michigan Proto Operators - N, HO, and O scale modelers in Michigan
- Mid-Atlantic Narrow Gauge Guild - Loose knit group of narrow gauge enthusiasts who reside mostly in the mid-Atlantic states from Connecticut to the Carolinas
- Mid-Central Region, NMRA - Serves Indiana, Ohio, West Virginia, Kentucky, and western Pennsylvania
- Mid-Eastern Region, NMRA - Includes the central states of the east coast, from New Jersey to North Carolina
- Mid-Mon Valley Model Railroad Club, NMRA - HO scale club in New Eagle, Pennsylvania
- Middlesex Central Railroad Club - HO scale club in Westford, Massachusetts
- Model Engineers Railroad Club of North Jersey - Operates a permanent layout in North Haledon, New Jersey
- Model Railroad Club of Buffalo - Operates HO and O scale layouts in Buffalo, New York
- Model Railroad Club of Toronto - O scale (2 rail) model railroad club with a 5000 sq ft layout; Toronto, Ontario, Canada
- Model Railroad Club, The - Operates HO and N scale layouts in Union, New Jersey
- Modélistes Ferroviaires de Gatineau - HO scale modelers in Gatineau, Québec, Canada
- Mohawk Valley Model Railroad Group - Model railroaders in the Southern Adirondack Mohawk Valley region of New York
- Mohegan-Pequot Model Railroad Club - Modular model railroad club in southeastern Connecticut operates layouts in HO, G, N, and On3 scales at train shows, museums, schools, and stores
- Moncton Model Railroad Society - Promotes model railroading and railroad history in Moncton, New Brunswick, Canada
- Montreal Railroad Modelers Association - Operates the HO scale Canada Central Railway with 4000 feet of track; Montreal, Quebec, Canada
- Moose Valley Model Railroaders Alliance - Group of prototype and freelance modelers who operate in a prototypical manner on several railroads in Pennsylvania
- Muskegon Railroad Historical Society - Preserves Michigan railroad history and operates O, HO, and N scale model railroad layouts; Muskegon, Michigan
- Nashua Valley Railroad Association - Operates an HO scale DCC controled layout in Shirley, Massachusetts
- Nassau Lionel Operating Engineers - O gauge model train club in Levittown, New York
- National Capital Trackers - Model train enthusiasts in the Washington DC area who share an interest in operating three rail O-gauge trains and constructing portable layout modules
- National Toy Train Museum - Standard gauge, O, S, G, HO, and Z scale layouts; Strasburg, Pennsylvania
- New England Free-mo Group - HO scale modular model railroaders building to the Free-mo standards
- New Haven Society of Model Engineers - HO and O scale club in Wallingford, Connecticut
- New Jersey Division, NMRA - Promotes model railroading in central and southern New Jersey
- New Jersey Southern N-Trak - N-Trak modular club in Collingswood, New Jersey
- New York Society of Model Engineers - Operates two large layouts in HO and O gauge in Carlstadt, New Jersey
- Niagara Frontier Region, NMRA - Includes western New York state, northwest Pennsylvania, and Ontario, Canada
- Niagara Orleans Model Railroad Engineers - Two modular layouts (HO and N) displayed at club shows across Western New York and Southern Ontario; Niagara Falls, New York
- NJ Hi-Railers - Operates a 185 foot long 3 rail O scale layout; Paterson, New Jersey
- Nordel Model Railroad Club - Operates an HO scale layout in Hockessin, Delaware
- North Central Region, NMRA - Michigan, northern Ohio and northeastern Indiana
- North Coast Division 4, Mid Central Region, NMRA - Serves Ohio's Cuyahoga, Lorain, Medina, Erie, and Huron counties
- North Penn S Gaugers - Encourages S gauge model railroaders in the North Penn area; Lansdale, Pennsylvania
- North Shore Model Railroad Club - HO and HOn3 model railroad in Wakefield (Boston), Massachusetts
- Northeast Hoosier Division, NMRA - Division 3 of the North Central Region, serving railroad enthusiasts in the northeastern counties of Indiana
- Northeast N-TRAK - Promotes N scale modular railroading; Wilmington, Massachusetts
- Northeastern Region, NMRA - Includes New York state, New England, and Quebec, Canada
- Northern Burlington Model Railroad Club - Operates the 800 sq ft Southern Pacific Cascade Divison HO gauge railroad in New Jersey
- Northern New Jersey N-Trak - Operates N scale layouts at train shows and other public events
- Northern Ohio Garden Railway Society - Garden railroaders in Northeast Ohio
- Northern Virginia Model Railroad - Models the Western North Carolina Railroad in HO scale, set in the 1950s; Vienna, Virginia
- Northern Virginia N-TRAK - N scale club with members in Northern Virginia, Maryland, and Washington DC
- Northlandz - Home of the Great American Railway with 8 miles of track and 100+ trains; Flemington, New Jersey
- Northwestern Vermont Model Railroad Society - Operates a 1200 square foot HO scale layout in Essex Junction, Vermont
- Norwalk and Western RR - HO scale modular club in Norwalk, Ohio
- Nutfield Valley Railroad Club - HO scale club in Derry, New Hampshire
- Nutmeg Division, NMRA - Covers the counties of Hartford, Litchfield, Middlesex, New Haven, New London, Tolland, and Windham in Connecticut and Hampden and Hampshire counties in Massachusetts
- Ocean County Society of Model Railroaders - Operates O and HO layouts in Lakewood, New Jersey
- Ohio Valley Free-Mo - HO scale model railroaders interested in module building and operations
- Old Colony Railroad Club - Model railroad club in Raynham, Massachusetts
- Ottawa Valley Associated Railroaders - Informal group of model railroaders in Ottawa, Ontario, Canada
- Ottawa Valley Garden Railroad Society - Garden railroading club in Ottawa, Ontario, Canada
- Ottawa Valley HOTrak Modular Railway Club - HO scale modular railroaders who are integrating double track and single track modules into very large free-form layouts that emphasize realistic operations through the use of a digital command control (DCC) system and waybills for car forwarding; Ottawa, Ontario, Canada
- Patcong Valley Model Railroaders - HO scale club in Richland Village, New Jersey
- Peninsular Modular Railroad Club - Promotes model railroading in the Battle Creek and Kalamazoo areas of Michigan
- Penn State Model Railroad Club - Operates HO, N, and Z scale layouts; University Park, Pennsylvania
- Pepperell Siding Model Railroad Club - Modular HO scale club in Pepperell, Massachusetts
- Philadelphia Division, NMRA - Serves Philadelphia and the surrounding Pennsylvania suburbs
- Piedmont Railroaders - Club devoted to all aspects of the railroad hobby; Warrenton, Virginia
- Pine Ridge Railroaders - Operates HO and N scale layouts in Oshawa, Ontario, Canada
- Pittsburgh Garden Railway Society - Operates G and O scale outdoor layouts in western Pennsylvania
- Portland Terminal Model Railroad Club - HO scale club in Portland, Maine
- Potomac Division, NMRA - Covers Northern Virginia, Washington DC, and Maryland
- Potomac Module Crew - Members of the Potomac Division (NMRA) with an interest in modular model railroading in Southern Maryland, Washington DC, and Virginia
- Prince William County Model Railroad Club - HO modular club in Quantico, Virginia, with a club layout that is displayed at events throughout the Washington DC metropolitan area
- Providence Model Railroad Club - Operates the freelance HO scale Providence Northern Railroad and sells limited run rolling stock; Warwick, Rhode Island
- Purdue Railroad Club - HO layout and railroad-related activities; West Lafayette, Indiana
- Quebec Model Railroad Society - Operates HO, N, and 1-1/2" scale layouts in Sainte-Foy, Quebec, Canada
- Rails on Wheels - HO modular model railroad club in Ann Arbor, Washtenaw County, Michigan
- Ramapo Valley Railroad - HO scale model railroad club in Ho-Ho-Kus, NJ
- Rappahannock Model Railroad Club - O gauge club in Fredericksburg, Virginia
- Reading Society of Model Engineers - Operates the 15" gauge Laurel Run Railroad located near Reading, Pennsylvania
- Redford Model Railroad Club - Metro Detroit, Michigan
- Rensselaer Model Railroad Society - Student organization at Rensselaer Polytechnic Institute in Troy, New York
- Riverbend Model Railroad Club - Operates the 32'x22' double level HO scale Superior Northern Railroad in Hudsonville, Michigan
- Roadside America - O gauge layout depicts life in rural America, open daily to the public in Shartlesville, Pennsylvania
- Rochester Area S Gaugers - S scale model railroading, including standard and narrow gauge models, hi-rail, and American Flyer operating and collecting; Rochester, New York
- Rochester Institute of Technology Model Railroad Club - Models the fictitious Rochester & Irondequoit Terminal in HO scale; Rochester, New York
- Rockland Model Train & Traction Club - Designs, constructs, and operates HO and O scale model railroads; Spring Valley, New York
- Rockville Model Railroad Society - Serves the Maryland suburbs of Washington DC, modeling in all popular scales from G to Z
- Ross Rails Model Train Club - HO scale satellite train club formed by members of the Greater Cincinnati Modular Railroad Association; Ross, Ohio
- Royal City Model Railroaders Association - Layout owners and operators near Guelph, Ontario, Canada
- Royersford Modular Model Railroaders - Modular club in the Royersford and Norristown area of Pennsylvania
- Rutland Railway Association - Operates HO and N scale layouts and the museum of the Rutland Railroad; Rutland, Vermont
- Saint Joe Valley Model Railroad Club - HO scale layout in Mishawaka, Indiana
- Saint John Society of Model Railroaders - Operates an HO modular model railroad in Saint John, NB, Canada
- Scarborough Model Railroaders - 1500 square foot HO scale layout and a 700 square foot N scale layout in Scarborough, Ontario, Canada
- Schuylkill Valley Model Railroad Club - HO scale club in Phoenixville, Pennsylvania
- Sebring Model Railroad Club - Home of the 25'x70' HO scale Ohio & Western Allegheny Railroad; Sebring, Ohio
- Severna Park Model Railroad Club - Home of the HO scale Chesapeake & Allegheny Railroad, spanning Maryland circa 1950; Severna Park, Maryland
- Shoreline Garden Railroad Club - G scale enthusiasts in southern Delaware and northeast Maryland
- South Eastern Pennsylvania Garden Railway Society - Large scale model railroad enthusiasts in the Delaware Valley, Pennsylvania
- South Jersey Garden Railroad Society - Model train enthusiasts from southern New Jersey
- South Jersey S Gaugers - Devoted to promoting all aspects of model railroading in S gauge, including hi-rail, scale, and narrow-gauge; Stratford, New Jersey
- South Oakland County Model Railroad Club - HO club modeling Grand Trunk Western in Hazel Park, Michigan
- South Shore Model Railway Club - HO scale club in Hingham, Massachusetts
- Southeastern Michigan S Gaugers - Devoted to American Flyer, High Rail, and S scale model railroading
- Southern New England Model Railroad Club - Operates a 21' by 83' modular O scale layout; Gardner, Massachusetts
- Southwestern Michigan Garden Railway Club - Outdoor G gauge model railroad in a landscaped garden setting, complete with bridges, tunnels, and buildings; Coloma, Michigan
- St. Albans Chesapeake and Ohio Modelers - Club for those who want to model the C&O and share the C&O's history through models; St. Albans, West Virginia
- St. Lawrence Division, NMRA - Division of the Niagara Frontier Region, serving eastern Ontario and northern New York
- Strasburg Model Railroad Club - Philadelphia and South Jersey area club with HO and G scale layouts
- Sunrise Trail Division, NMRA - Includes Bronx, Kings, Nassau, New York, Queens, and Suffolk counties in New York
- Susquehanna Division, NMRA - Division 11 of the NMRA's Mid-Eastern Region, serving central Pennsylvania with clinics, train meets, and an all scale modular program
- Susquehanna S-Gaugers - Promotes all forms of S gauge in central Pennsylvania
- Susquehanna Valley Garden Railway Society - Central Pennsylvania garden railway club
- Sussex County Railroad Club - Group of railroad enthusiasts, both prototypical and model, in Hamburg, New Jersey
- Swanton Area Railroad and Model Club - O, HO, and N scales modular displays in Swanton, Ohio
- Syracuse Model Railroad Club - Permanent and modular HO scale layouts in Syracuse, New York
- Tailspin Hobbies Model Railroad Club - HO scale club in Apollo, Pennsylvania
- TCA Eastern Division - Chapter of the Train Collectors Association in York, Pennsylvania
- TCA Keystone Division - Train collectors in the Pennsylvania counties of Cumberland, Perry, Adams, York, Berks, Lancaster, Lebanon, and Dauphin
- TCA Metropolitan Division - Division of the Train Collectors Association serving New York City, North Jersey, and the surrounding area
- TCA New England Division - Association of toy train collectors in New England
- TCA WB&A Chapter - Washington, Baltimore, and Annapolis chapter of the Train Collectors Association
- TCA West Michigan Chapter - Train collectors meet monthly in Grand Rapids, Michigan
- Tech Model Railroad Club of MIT - Cambridge, Massachusetts
- The Railroad Model and Historical Society of Southeastern Ohio - Athens, Ohio
- Toy Train Collectors Society - New York organization devoted to the collection, preservation, and operation of the electric trains
- Trainmasters of Babylon Model Train Club - O gauge club in West Babylon, Long Island, New York
- Upstate Model Railroaders - Operates N, HO, O, and G scale layouts in Glens Falls, New York
- Valley N-Trak of Connecticut - Model railroad enthusiasts promoting the N scale module concept; Oxford, Connecticut
- Washington, Virginia & Maryland Garden Railway Society - G scale garden railroaders
- Waterloo Region Model Railway Club - Modeling CP Rail's Sudbury Division as it was in the 1970s; Maryhill, Ontario, Canada
- Wenham Museum - Six operating layouts in G, O, HO, N, and Z gauges in Wenham, Massachusetts
- Western Pennsylvania Model Railroad Museum - Promotes and preserves the history of railroads in western Pennsylvania through the hobby of model railroading; Gibsonia, Pennsylvania (just north of Pittsburgh)
- Western Reserve Division, NMRA - Serving NMRA members in the Ohio counties of Lake, Geauga, and Ashtabula
- Windsor Modular Railroad Club - Modular railroad club in Windsor, Ontario, Canada
- Worcester Model Railroaders, Inc. - Freelance DCC operated HO scale Worcester Central Lines layout; Dudley, Massachusetts
- York Railway Modellers - Operates an HO scale layout with an emphasis on the prototype practices of CN and CP in Southern Ontario during the 1950s; Toronto, Ontario, Canada
- Youth In Model Railroading - National model railroad club for children age 8 to 18
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